In a standard trial to evaluate the action of antidepressants called the forced swimming test, three researchers and four male researchers discovered that ketamine acted as an antidepressant only when administered by men. When the researchers placed a T-shirt worn by a man next to the mice in the fume hood, the animals with ketamine swam for longer than those treated with a placebo. This made them think that the masculine scent was necessary for the drug to work.

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